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Bild på Shai Mulinari. Privat bild.

Shai Mulinari

Docent och Forskare

Bild på Shai Mulinari. Privat bild.

Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.

Författare

  • Shai Mulinari
  • Udo Häcker

Summary, in English

The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.

Avdelning/ar

  • Sociologi
  • Utvecklingsbiologi i invertebrater, Udo Häckers grupp

Publiceringsår

2009

Språk

Engelska

Sidor

3875-3880

Publikation/Tidskrift/Serie

Development: For advances in developmental biology and stem cells

Volym

136

Issue

23

Dokumenttyp

Artikel i tidskrift

Förlag

The Company of Biologists Ltd

Ämne

  • Developmental Biology

Status

Published

Forskningsgrupp

  • Invertebrate Developmental Biology, Udo Haecker's group

ISBN/ISSN/Övrigt

  • ISSN: 1477-9129