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Bild på Shai Mulinari. Privat bild.

Shai Mulinari

Docent | Universitetslektor

Bild på Shai Mulinari. Privat bild.

Aligning digital biomarker definitions in psychiatry with the National Institute of Mental Health Research Domain Criteria framework

Författare

  • Shai Mulinari

Summary, in English

The field of biological psychiatry faces a growing influx of digital biomarkers spanning self-report, social, behavioral, cognitive, and physiological indicators of various mental health conditions. However, the definition of “digital biomarker,” particularly the “bio-” component, remains unclear. This article reviews the terminology of digital biomarkers in psychiatry and argues for the reservation of the term exclusively for measures of biological parameters with a plausible pathway connecting to the disease or condition of interest to enhance terminological clarity and consistency with conventional definitions of biomarker, short for biological marker. While the distinction between biological and non-biological parameters may blur at the edges, the Research Domain Criteria (RDoC) developed by the US National Institute of Mental Health offers a valuable heuristic. The RDoC distinguishes between biological (genes, molecules, cells, neural circuits, physiology) and non-biological (broadly understood behavior and self-report) units of analysis. Aligning digital biomarker definitions in psychiatry with the RDoC framework would mark a significant shift from the current broad usage, where almost any digitally measured characteristic, when used as an indicator, qualifies as a digital biomarker.

Avdelning/ar

  • Sociologi

Publiceringsår

2024-10-13

Språk

Engelska

Publikation/Tidskrift/Serie

NPP—Digital Psychiatry and Neuroscience

Volym

2

Dokumenttyp

Artikel i tidskrift

Förlag

Nature Publishing Group

Ämne

  • Social Psychology

Aktiv

Published

Projekt

  • The New Scientific Revolution? AI and Big Data in Biomedicine

ISBN/ISSN/Övrigt

  • ISSN: 2948-1570